Hydrochloric Acid → HCID 68593867, compound

HRID 883273Notes

Reaction equation

HRID 883273 reaction equation
[ClH:1].[CH3:2][N:3]([CH3:22])[C@@H:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[C:14]2[C:15]([CH3:21])=[N:16][N:17]([CH3:20])[C:18]=2[CH3:19])[CH2:5]1>CCOCC>[ClH:1].[ClH:1].[CH3:22][N:3]([CH3:2])[C@@H:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[C:14]2[C:15]([CH3:21])=[N:16][N:17]([CH3:20])[C:18]=2[CH3:19])[CH2:5]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 25070945HCID 25070945, compound

Product 1

HCID 68593867HCID 68593867, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

HCl (9.2 mL, 4 M solution in dioxane, 18.51 mmol) was dropwise added to a suspension of (2R)-dimethyl-[5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydro-naphthalen-2-yl]amine (1.75 g, 6.17 mmol) in Et2O (10 mL). The reaction mixture was stirred at room temperature for 3 h and then the solvent was concentrated off. The resulting solid was suspended in Et2O (25 mL) and concentrated, in order to remove excess of HCl. This operation was done for three times, to give 1.95 g of the title product (Rf=0.2 (10% Et3N/AcOEt), white solid, 99% yield).

Workup

  1. concentrationthe solvent was concentrated off
  2. concentrationconcentrated, in order
  3. customto remove excess of HCl

Sources & evidence

ORD record
ord-6fd8865bc4fa459684719670211e8c22
Source dataset
uspto-grants-2012_08
Patent number
US08236845B2

Reaction notes

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