Hydrochloric Acid → HCID 68593782, compound

Participants

Reaction Steps

Then, HCl (0.750 mL, 2 M solution in Et20, 1.5 mmol) was dropwise added to a suspension of (2S)-[5-(3,5-Dimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-dimethyl-amine (129 mg, 0.48 mmol) in Et2O (5 mL). The reaction mixture was stirred at room temperature for 5 h and then the solvent was concentrated off. The resulting solid was suspended in Et2O (5 mL) and concentrated, in order to remove excess of HCl. This operation was done for three times, to give 119 mg of the title product (white solid, 81% yield).

Provenance & Evidence