Hydrochloric Acid → HCID 68593782, compound

HRID 883274Notes

Reaction equation

HRID 883274 reaction equation
[ClH:1].[CH3:2][C:3]1[C:7]([C:8]2[CH:17]=[CH:16][CH:15]=[C:14]3[C:9]=2[CH2:10][CH2:11][C@H:12]([N:18]([CH3:20])[CH3:19])[CH2:13]3)=[C:6]([CH3:21])[NH:5][N:4]=1>CCOCC>[ClH:1].[ClH:1].[CH3:21][C:6]1[C:7]([C:8]2[CH:17]=[CH:16][CH:15]=[C:14]3[C:9]=2[CH2:10][CH2:11][C@H:12]([N:18]([CH3:19])[CH3:20])[CH2:13]3)=[C:3]([CH3:2])[NH:4][N:5]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59293496HCID 59293496, compound

Product 1

HCID 68593782HCID 68593782, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Then, HCl (0.750 mL, 2 M solution in Et20, 1.5 mmol) was dropwise added to a suspension of (2S)-[5-(3,5-Dimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-dimethyl-amine (129 mg, 0.48 mmol) in Et2O (5 mL). The reaction mixture was stirred at room temperature for 5 h and then the solvent was concentrated off. The resulting solid was suspended in Et2O (5 mL) and concentrated, in order to remove excess of HCl. This operation was done for three times, to give 119 mg of the title product (white solid, 81% yield).

Workup

  1. concentrationthe solvent was concentrated off
  2. concentrationconcentrated, in order
  3. customto remove excess of HCl

Sources & evidence

ORD record
ord-a950a9b6c013403baa50be5f5c887b97
Source dataset
uspto-grants-2012_08
Patent number
US08236845B2

Reaction notes

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