1-(2-Fluorophenyl)piperazine → HCID 68560972, compound

HRID 883430Notes

Reaction equation

HRID 883430 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH2:13][CH2:14][CH:15]=O)=[CH:11][C:10]([CH2:17][CH2:18][CH2:19][CH3:20])=[N:9]2)=[CH:4][CH:3]=1.[F:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>>[F:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][N:31]([CH2:15][CH2:14][CH2:13][C:12]2[N:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)[N:9]=[C:10]([CH2:17][CH2:18][CH2:19][CH3:20])[CH:11]=2)[CH2:30][CH2:29]1

Participants

4

Reactant 3

HCID 705291-(2-Fluorophenyl)piperazineHCID 5049666Sodium triacetoxyborohydrideHCID 86639948HCID 86639948, compound

Product 1

HCID 68560972HCID 68560972, compound

Procedure

98.4 mg (78.5%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-(4-chlorophenyl)-3-butyl-1H-pyrazol-5-yl)propanal (80.1 mg, 0.275 mmol), 1-(2-fluorophenyl)piperazine (65 mL, 0.413mmol), and NaBH(OAc)3 (198 mg, 0.936 mmol).

Workup

  1. custom98.4 mg (78.5%) of target compound was obtained

Sources & evidence

ORD record
ord-2dfe18595fa8493193034a1cb49158a2
Source dataset
uspto-grants-2012_08
Patent number
US08236806B2

Reaction notes

Loading…