Water → HCID 25026399, compound

HRID 883440Notes

Reaction equation

HRID 883440 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]([C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)=[O:11])=[CH:4][C:3]=1[O:19][CH3:20].O>O1CCCC1.[Pd]>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)=[O:11])=[CH:4][C:3]=1[O:19][CH3:20]

Participants

5

Reactant 2

HCID 962WaterHCID 667388783-(4-Hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one

Product 1

HCID 25026399HCID 25026399, compoundYield 89.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalyst2×HCID 8028TetrahydrofuranSolvent

Procedure

3-(4-Hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propene-1-one (10 g) is dissolved in 100 g tetrahydrofuran, 0.2 g of Pd on activated carbon (Pd content: about 5% by weight, water content approx. 50% by weight, based on the total mass of the catalyst) is added and a hydrogenation is carried out at normal pressure and room temperature (approx. 20° C.). After removal of the catalyst and the solvent, 9 g of 3-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)-propane-1-one is obtained. Yield: 89% of the theory.

Workup

  1. additionis added
  2. customis carried out at normal pressure and room temperature (approx. 20° C.)
  3. customAfter removal of the catalyst

Sources & evidence

ORD record
ord-28d759f832864cb5b51c191afbb286bd
Source dataset
uspto-grants-2012_08
Patent number
US08236859B2

Reaction notes

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