反应详情

A solution of thioacetamide (132 mmol, 1.0 eq) in MeCN (250 mL) is added to a mixture of the respective 3-chloro-2-oxo-propionic acid methyl ester derivative (132 mmol, 1.0 eq) and molecular sieves (4 Å, 12 g) in MeCN (60 mL). After stirring for 5 h the mixture is cooled in an ice-bath and the obtained precipitate is filtered off. The residue is washed with cold MeCN, dried, dissolved in MeOH (280 mL) and stirred at 50° C. for 6 h. The solvents are removed in vacuo to give the corresponding 2-methyl-thiazole-4-carboxylic acid methyl ester derivatives.

1. temperatureis cooled in an ice-bath
2. filtrationthe obtained precipitate is filtered off
3. washThe residue is washed with cold MeCN
4. customdried
5. dissolutiondissolved in MeOH (280 mL)
6. stirringstirred at 50° C. for 6 h
7. customThe solvents are removed in vacuo