Trifluoroacetic acid → HCID 72254565, compound

HRID 883635Notes

Reaction equation

HRID 883635 reaction equation
C(OC([N:8]1[CH:12]([CH2:13][NH:14][C:15](=[O:20])[C:16]([F:19])([F:18])[F:17])[CH2:11][S:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:18][C:16]([F:17])([F:19])[C:15]([NH:14][CH2:13][CH:12]1[CH2:11][S:10][CH2:9][NH:8]1)=[O:20]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 72254566HCID 72254566, compound

Product 1

HCID 72254565HCID 72254565, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a cold (0° C.) solution of 4-[(2,2,2-trifluoro-acetylamino)-methyl]-thiazolidine-3-carboxylic acid tert-butyl ester (19 mmol) in dry DCM (10 mL) was added dropwise TFA (133 mmol, 7 eq). The reaction mixture was stirred for 20 h and concentrated in vacuo to give the title compound. LC-MS: tR=0.24 min; [m+H]+=214.99.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-0a41be9387a6457faf22b1710d14f2d1
Source dataset
uspto-grants-2012_08
Patent number
US08236964B2

Reaction notes

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