Potassium Cyanide → HCID 67424339, compound

HRID 883643Notes

Reaction equation

[C:1](/[C:3](=[C:8]1/[C:9](=[O:19])[NH:10][C:11]2[C:16]/1=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)/[C:4]([O:6][CH3:7])=[O:5])#[N:2].[C-:20]#[N:21].[K+]>>[C:1]([CH:3]([C:8]1([C:20]#[N:21])[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH3:18])[CH:15]=2)[NH:10][C:9]1=[O:19])[C:4]([O:6][CH3:7])=[O:5])#[N:2]

Participants

Reactant 2

HCID 9032Potassium Cyanide

HCID 67424537HCID 67424537, compound2×

Product 1

HCID 67424339HCID 67424339, compoundYield 90%

Procedure

Following the general method as outlined for Intermediate 5, starting from methyl (2Z)-cyano(5-methoxy-2-oxo-1,2-dihydro-3H-indol-3-ylidene)acetate (intermediate 2) and potassium cyanide, the title compound was isolated, after evaporation, as a pale brown solid in 90% yield. This was a mixture of diastereomers.

Sources & evidence

ORD record: ord-c5f012a0a2924363b8cea73a89a160cc
Source dataset: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08236963B2

Reaction notes

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