Potassium Cyanide → HCID 86761599, compound

HRID 883645Notes

Reaction equation

HRID 883645 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5](/[C:6](=[C:12](\[C:17]#[N:18])/[C:13]([O:15][CH3:16])=[O:14])/[C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1.[C-:19]#[N:20].[K+]>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([CH:12]([C:17]#[N:18])[C:13]([O:15][CH3:16])=[O:14])([C:19]#[N:20])[C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 9032Potassium CyanideHCID 67424997HCID 67424997, compound2×

Product 1

HCID 86761599HCID 86761599, compoundYield 61%

Procedure

Following the general method as outlined for Intermediate 5, starting from methyl (2Z)-(6-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)(cyano)acetate (intermediate 4) and potassium cyanide, the title compound was isolated, after evaporation, as a light brown solid in 61% yield. This was a mixture of diastereomers.

Sources & evidence

ORD record
ord-f1db4c1a66804b12bde2dbb45938e376
Source dataset
uspto-grants-2012_08
Patent number
US08236963B2

Reaction notes

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