反应详情

An ice-cold solution of tert-butyl [5′-chloro-1-(5-chloro-2-fluorobenzyl)-2,2′,5-trioxospiro[imidazolidine-4,3′-indol]-1′(2′H)-yl]acetate (168.00 mg; 0.33 mmol) in DCM (4.00 ml) was treated with trifluoroacetic acid (1.00 ml). After stirring for 4 hours the reaction the solvents were evaporated. Toluene was added twice and evaporated to give the titla compound as a beige solid in 67.5% yield (96.1% purity by HPLC). MS (ESI+): 452.1; MS (ESI−): 454.4

1. customthe reaction the solvents
2. customwere evaporated
3. additionToluene was added twice
4. customevaporated