Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → HCID 178517692, compound

HRID 883905Notes

Reaction equation

HRID 883905 reaction equation
CO[CH:3](OC)[CH2:4][C:5]1[N:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7]([NH2:9])=[O:8].[NH+]1C=CC=CC=1.C1(C)C=CC(S([O-])(=O)=O)=CC=1>C1C=CC=CC=1>[N:13]1[C:5]2[CH:4]=[CH:3][N:9]=[C:7]([OH:8])[C:6]=2[CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)HCID 134111212-(2,2-Dimethoxyethyl)nicotinamide

Product 1

HCID 178517692HCID 178517692, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

The product from Example 36c (1.36 g, 6.47 mmol) was dissolved in benzene (35 ml) and to this solution was added pyridinium-para-toluenesulfonate (0.20 g, 0.8 mmol). The mixture was heated to reflux for 23 h then concentrated under vacuum to give the title compound in quantitative yield sufficiently pure for use as isolated.

Workup

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 23 h
  3. concentrationthen concentrated under vacuum

Sources & evidence

ORD record
ord-4a620eb7c4014d7da2ccc8d8eb059c1d
Source dataset
uspto-grants-2012_08
Patent number
US08236950B2

Reaction notes

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