HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-{4-[1-(4-Bromo-phenyl)-ethoxy]-2-nitro-phenylsulfanyl}-phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Mercaptophenol | HCID 240147 | — |
| Reactant | 4-[1-(4-Bromo-phenyl)-ethoxy]-1-chloro-2-nitro-benzene | HCID 66808423 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-{4-[1-(4-Bromo-phenyl)-ethoxy]-2-nitro-phenylsulfanyl}-phenol | HCID 66808220 | 68.2% |
Reaction Steps
The product from Example 44B (1.15 g, 3.22 mmol) was reacted with 4-mercapto-phenol (403 mg, 3.22 mmol) and K2CO3 (890 mg, 6.44 mmol) in 25 mL of DMF at 80° C. for 18 h. Cooled to room temperature and poured into water. Extracted with CH2Cl2 and washed several times with water. Dried over Na2SO4, filtered and concentrated under vacuum giving the title compound (980 mg, 68%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08236950B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-accd76cb3dc04d889c1a65c15b5b877b |
| Source note | uspto-grants-2012_08 |