反应详情

To a solution of 3-nitrobenzyl chloride (1.0 g, 5.83 mmol), 3-bromophenol (1.01 g, 5.83 mmol) and potassium carbonate (806 mg, 5.83 mmol) in acetone (25 mL) was heated to reflux for 23 hours. After cooling the solid was filtered off and the filtrate was concentrated under vacuum to a yellow residue which was dissolved in ethyl acetate (50 mL) and washed with 1N aqueous sodium hydroxide solution (25 mL) and water (25 mL) then dried and concentrated under vacuum to the title compound as a white solid (1.64 g, 91%).

1. temperatureto reflux for 23 hours
2. temperatureAfter cooling the solid
3. filtrationwas filtered off
4. concentrationthe filtrate was concentrated under vacuum to a yellow residue which
5. dissolutionwas dissolved in ethyl acetate (50 mL)
6. washwashed with 1N aqueous sodium hydroxide solution (25 mL) and water (25 mL)
7. customthen dried
8. concentrationconcentrated under vacuum to the title compound as a white solid (1.64 g, 91%)