5-Methyl-2-phenylsulfanyl-phenylamine → 7-cyclopropyl-N-(5-methyl-2-phenylsulfanyl-phenyl)pyrido[2,3-d]pyrimidin-4-amine

Participants

Role	Name	HCID	Charge
Reactant	5-Methyl-2-phenylsulfanyl-phenylamine	HCID 43349603	—
Reactant	4-(2-Amino-4-methyl-phenylsulfanyl)-phenol	HCID 66808123	—
Reactant	N'-(3-Cyano-6-cyclopropyl-pyridin-2-yl)-N,N-dimethyl-formamidine	HCID 66808412	—
Reactant	N'-(3-Cyano-6-methyl-pyridin-2-yl)-N,N-dimethyl-formamidine	HCID 66808573	—
Product	7-cyclopropyl-N-(5-methyl-2-phenylsulfanyl-phenyl)pyrido[2,3-d]pyrimidin-4-amine	HCID 57391392	—

Reaction Steps

The product from Example 7f was reacted with the product from Example 77A using the procedure from Example 73 substituting the product from Example 7f for the product from Example 9c and substituting the product from Example 77A for the product from Example 10B to provide the crude residue which was purified by trituration with methanol to provide the title compound. 1H NMR (300 MHz, DMSO-D6) δ ppm: 1.05-1.19 (m, 4 H), 2.22-2.41 (m, 1 H), 2.35 (s, 3 H), 7.05-7.31 (m, 7 H), 7.37 (s, 1 H), 7.58 (d, J=8.46 Hz, 1 H), 8.50 (s, 1 H), 8.65 (d, J=8.46 Hz, 1 H), 10.21 (s, 1 H); MS (ESI)+ m/z 385 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08236950B2
Source dataset	uspto-grants-2012_08
ORD ID	ord-0e7ff9821b6c4fc58699c684b572c616
Source note	uspto-grants-2012_08