Dimethylformamide dimethyl acetal → HCID 66808327, compound

HRID 883980Notes

Reaction equation

HRID 883980 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[CH:6][C:5]([C:10]#[N:11])=[C:4]([CH3:12])[N:3]=1.CO[CH:15](OC)[N:16]([CH3:18])[CH3:17]>C1(C)C=CC=CC=1>[C:8]([C:7]1[C:2]([N:1]=[CH:15][N:16]([CH3:18])[CH3:17])=[N:3][C:4]([CH3:12])=[C:5]([C:10]#[N:11])[CH:6]=1)#[N:9]

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 27867262-Amino-6-methylpyridine-3,5-dicarbonitrile

Product 1

HCID 66808327HCID 66808327, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 2-Amino-6-methyl-pyridine-3,5-dicarbonitrile (0.158 g, 1.0 mmol) and N,N-Dimethylformamide dimethyl acetal (0.119 g, 1.0 mmol) in toluene (10 mL) was heated at reflux for 6 hours. After cooling to room temperature, the solution was concentrated under vacuum to provide the title compound as a brown solid (0.2 g, 94%).

Workup

  1. temperatureat reflux for 6 hours
  2. concentrationthe solution was concentrated under vacuum

Sources & evidence

ORD record
ord-85a5cbe9840641139fb5fac0b6aab6d5
Source dataset
uspto-grants-2012_08
Patent number
US08236950B2

Reaction notes

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