反应详情

温度

0 °C

2,2-dimethyl-3-hydroxypropionic acid (11.8 g, 100 mmol) was dissolved in pyridine (30 mL), and the reaction solution was cooled to 0° C. Acetyl chloride (11.8 g, 15.0 mmol) was slowly added dropwise, the temperature was then raised to room temperature, and the reaction solution was stirred at room temperature for 3 hours. After the reaction was completed, 1N HCl (30 mL) was added to adjust pH to 3-4, and then the reaction mixture was extracted with EtOAc. The organic extracts were washed with 1N HCl, 4-5 times, dried over MgSO4, and concentrated in vacuo, give the title compound (15.2 g, 95.0%)

1. temperaturethe temperature was then raised to room temperature
2. extractionthe reaction mixture was extracted with EtOAc
3. washThe organic extracts were washed with 1N HCl, 4-5 times
4. dry with materialdried over MgSO4
5. concentrationconcentrated in vacuo