Oxalyl chloride → 2,2-Dimethyl-3-acetyloxypropionyl chloride

HRID 884027Notes

Reaction equation

HRID 884027 reaction equation
[CH3:1][C:2]([CH3:11])([CH2:6][O:7][C:8](=[O:10])[CH3:9])[C:3](O)=[O:4].C(Cl)(=O)C([Cl:15])=O>C1C=CC=CC=1>[CH3:1][C:2]([CH3:11])([CH2:6][O:7][C:8](=[O:10])[CH3:9])[C:3]([Cl:15])=[O:4]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 131926213-(Acetyloxy)-2,2-dimethylpropanoic acid2×

Product 1

HCID 111946632,2-Dimethyl-3-acetyloxypropionyl chloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Conditions

Temperature
0 °C

Procedure

The product of Step A, 2,2-dimethyl-3-acetyloxypropionic acid (11.76 g, 80 mmol) was dissolved in benzene (100 mL), and the reaction solution was cooled to 0° C., and then oxalyl chloride (15.0 g, 120 mmol) was slowly added dropwise. After 3 hours, the solvent was removed in vacuo, and the reaction mixture was distilled in vacuo to give the title compound.

Workup

  1. customthe solvent was removed in vacuo
  2. distillationthe reaction mixture was distilled in vacuo

Sources & evidence

ORD record
ord-88ed388f931b4d5291ae7044d15c10ac
Source dataset
uspto-grants-2012_08
Patent number
US08236955B2

Reaction notes

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