Hydrochloric Acid → HCID 178481070, compound

HRID 884044Notes

Reaction equation

HRID 884044 reaction equation
C([N:8]1[CH2:12][C@@H:11]([C:13]([N:15]2[CH2:19][C@@H:18]([N:20]([C@H:28]3[CH2:33][CH2:32][C@@H:31]([CH3:34])[CH2:30][CH2:29]3)[C:21]([C@@H:23]3[CH2:27][CH2:26][CH2:25][O:24]3)=[O:22])[CH2:17][C@H:16]2[C:35]([N:37]2[CH2:42][CH2:41][N:40]([CH3:43])[CH2:39][CH2:38]2)=[O:36])=[O:14])[C@H:10]([C:44]2[CH:49]=[CH:48][C:47]([Cl:50])=[CH:46][CH:45]=2)[CH2:9]1)(OC(C)(C)C)=O.Cl>C(Cl)Cl>[Cl:50][C:47]1[CH:46]=[CH:45][C:44]([C@@H:10]2[CH2:9][NH:8][CH2:12][C@H:11]2[C:13]([N:15]2[C@H:16]([C:35]([N:37]3[CH2:38][CH2:39][N:40]([CH3:43])[CH2:41][CH2:42]3)=[O:36])[CH2:17][C@H:18]([N:20]([C@H:28]3[CH2:33][CH2:32][C@@H:31]([CH3:34])[CH2:30][CH2:29]3)[C:21]([C@@H:23]3[CH2:27][CH2:26][CH2:25][O:24]3)=[O:22])[CH2:19]2)=[O:14])=[CH:49][CH:48]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178481071HCID 178481071, compound

Product 1

HCID 178481070HCID 178481070, compoundYield 99.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-BOC-(3R,4S)-3-(4-chlorophenyl)-4-({(2S,4S)-4-{(cis-4-methylcyclohexyl)[(2S)-tetrahydrofuran-2-ylcarbonyl]amino}-2-[(4-methylpiperazin-1-yl)carbonyl]pyrrolidin-1-yl}carbonyl)pyrrolidine (1.18 g, 1.65 mmol) obtained in Step A was dissolved in DCM (1 mL). 4M HCl (1 mL) was added dropwise thereto. The reaction solution was stirred for 1 hour at room temperature, concentrated in vacuo to give the title compound (1.01 g, 99.8%).

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-644b7abb16c14b2386bcab538ed7d392
Source dataset
uspto-grants-2012_08
Patent number
US08236955B2

Reaction notes

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