3,4-Dichlorophenyl isocyanate → HCID 68528865, compound

HRID 884113Notes

Reaction equation

HRID 884113 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][C:16]([O:18][CH3:19])=[O:17])=[CH:11][CH:10]=2)=[N:6][CH:7]=1.[Cl:20][C:21]1[CH:22]=[C:23]([N:28]=[C:29]=[O:30])[CH:24]=[CH:25][C:26]=1[Cl:27].C(OC(C)C)(C)C>ClCCl>[Cl:20][C:21]1[CH:22]=[C:23]([NH:28][C:29](=[O:30])[NH:1][C:2]2[CH:3]=[CH:4][C:5]([O:8][C:9]3[CH:14]=[CH:13][C:12]([CH2:15][C:16]([O:18][CH3:19])=[O:17])=[CH:11][CH:10]=3)=[N:6][CH:7]=2)[CH:24]=[CH:25][C:26]=1[Cl:27]

Participants

5

Reactant 3

HCID 76073,4-Dichlorophenyl isocyanateHCID 7914Diisopropyl EtherHCID 68527035HCID 68527035, compound

Product 1

HCID 68528865HCID 68528865, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of methyl 2-[4-(5-aminopyridin-2-yloxy)phenyl]acetate (0.44 g, 1.7 mmol) in dichloro-methane (7 mL) was added 3,4-dichlorophenylisocyanate (0.353 g, 1.9 mmol), and the resulting reaction solution was stirred for 1 hour at room temperature. To the reaction solution was added diisopropyl ether. Insoluble matter was removed by filtration, to thereby yield 0.60 g of the title compound.

Workup

  1. customthe resulting reaction solution
  2. customInsoluble matter was removed by filtration

Sources & evidence

ORD record
ord-cfd0476a6a824d2b8b4f7621506a4c95
Source dataset
uspto-grants-2012_08
Patent number
US08236826B2

Reaction notes

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