3,4-Dichlorobenzaldehyde → HCID 68528874, compound

HRID 884165Notes

Reaction equation

HRID 884165 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][NH:16][CH2:17][C:18]([N:20]3[CH2:25][CH2:24][N:23]([CH2:26][C:27]4[CH:35]=[CH:34][C:33]5[O:32][CH2:31][O:30][C:29]=5[CH:28]=4)[CH2:22][CH2:21]3)=[O:19])=[CH:11][CH:10]=2)=[N:6][CH:7]=1.[Cl:36][C:37]1[CH:38]=[C:39]([CH:42]=[CH:43][C:44]=1[Cl:45])[CH:40]=O>CO>[Cl:36][C:37]1[CH:38]=[C:39]([CH:42]=[CH:43][C:44]=1[Cl:45])[CH:40]=[N:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:15][NH:16][CH2:17][C:18]([N:20]3[CH2:25][CH2:24][N:23]([CH2:26][C:27]4[CH:35]=[CH:34][C:33]5[O:32][CH2:31][O:30][C:29]=5[CH:28]=4)[CH2:22][CH2:21]3)=[O:19])=[CH:13][CH:14]=2)=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 227103,4-DichlorobenzaldehydeHCID 86616540HCID 86616540, compound

Product 1

HCID 68528874HCID 68528874, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-{[(4-(5-aminopyridin-2-yloxy)phenyl]methylamino}-1-(4-piperonylpiperazin-1-yl)ethanone (7.80 g, 16.4 mmol) was dissolved in methanol (400 mL), and to the resulting solution was added 3,4-dichlorobenzaldehyde (2.87 g, 16.4 mmol). This solution was refluxed for 16 hours. The resulting reaction solution was concentrated under reduced pressure, to thereby yield 10.4 g of the title compound.

Workup

  1. temperatureThis solution was refluxed for 16 hours
  2. customThe resulting reaction solution
  3. concentrationwas concentrated under reduced pressure

Sources & evidence

ORD record
ord-df6c8dca0e3948bab87492b0af90de1a
Source dataset
uspto-grants-2012_08
Patent number
US08236826B2

Reaction notes

Loading…