反应详情

4 ml of water/ethanediol (1:1) were added to 1.0 g (7.4 mmol) of 4-(3,4-dichlorophenyl)-5-methoxy-2-methyl-2H-pyridazin-3-one and 0.4 g of potassium hydroxide (2 eq), and the mixture was reacted at 150° C. overnight. The reaction mixture was added to 50 ml of water and adjusted to pH 1 using concentrated hydrochloric acid, and the resulting precipitate was filtered off. Recrystallization from isopropanol gave 0.2 g of pure product.

1. customthe mixture was reacted at 150° C. overnight
2. filtrationthe resulting precipitate was filtered off
3. customRecrystallization from isopropanol