Ammonium formate → HCID 25253040, compound

HRID 884489Notes

Reaction equation

HRID 884489 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[N:15]([CH:19]1[CH2:24][CH2:23][N:22]([CH:25]=[O:26])[CH2:21][CH2:20]1)[C:14](=[O:27])[N:13]([CH2:28][C:29]1[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[C:31]([O:37][CH3:38])[CH:30]=1)[C:12]2=[O:39])C1C=CC=CC=1.C([O-])=O.[NH4+]>CCO.[Pd]>[CH3:38][O:37][C:31]1[CH:30]=[C:29]([CH:34]=[CH:33][C:32]=1[O:35][CH3:36])[CH2:28][N:13]1[C:12](=[O:39])[C:11]2[C:16](=[CH:17][CH:18]=[C:9]([OH:8])[CH:10]=2)[N:15]([CH:19]2[CH2:24][CH2:23][N:22]([CH:25]=[O:26])[CH2:21][CH2:20]2)[C:14]1=[O:27]

Participants

5

Reactant 2

HCID 2723923Ammonium formateHCID 595871404-[6-(Benzyloxy)-3-(3,4-dimethoxybenzyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]piperidine-1-carbaldehyde

Product 1

HCID 25253040HCID 25253040, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 0.618 g of 4-[6-(benzyloxy)-3-(3,4-dimethoxybenzyl)-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl]piperidine-1-carbaldehyde obtained in stage 1.7, 0.44 g of ammonium formate and 0.124 g of Pd/C (10%) in 10 ml of EtOH purged beforehand with nitrogen is irradiated under a microwave field at 80° C. for 2 h 00. The mixture is filtered and the filtrate is evaporated under reduced pressure to give 0.513 g of the expected product.

Workup

  1. customis irradiated under a microwave field at 80° C. for 2 h 00
  2. filtrationThe mixture is filtered
  3. customthe filtrate is evaporated under reduced pressure

Sources & evidence

ORD record
ord-a1d32842a0534ea2ae505c4a923cc38b
Source dataset
uspto-grants-2012_08
Patent number
US08242126B2

Reaction notes

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