Formamide → HCID 178513603, compound

HRID 884646Notes

Reaction equation

HRID 884646 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:13][C:12](=[O:14])[N:11]=[C:10]([C:15]2[S:19][C:18]([C:20]([OH:22])=O)=[CH:17][CH:16]=2)[CH:9]=1.C([NH2:25])=O>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:13][C:12](=[O:14])[N:11]=[C:10]([C:15]2[S:19][C:18]([C:20]([NH2:25])=[O:22])=[CH:17][CH:16]=2)[CH:9]=1

Participants

3

Reactant 2

HCID 713FormamideHCID 178524203HCID 178524203, compound

Product 1

HCID 178513603HCID 178513603, compound

Conditions

Temperature
200 °C

Procedure

5-[6-(2-Chlorophenyl)-2-oxo-1,2-dihydropyrimidin-4-yl]thiophene-2-carboxylic acid (100 mg, 0.30 mmol) was suspended in 1 mL of formamide. The reaction mixture was stirred for 30 minutes at 200° C. After cooling, the precipitate was filtered, dissolved in 1 mL dimethylformamide and purified by reverse phase HPLC. 30 mg of product were isolated.

Workup

  1. temperatureAfter cooling
  2. filtrationthe precipitate was filtered
  3. dissolutiondissolved in 1 mL dimethylformamide
  4. custompurified by reverse phase HPLC

Sources & evidence

ORD record
ord-b48fd45743434e1686b4c13f38aac827
Source dataset
uspto-grants-2012_08
Patent number
US08242129B2

Reaction notes

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