反应详情

A 100 mL round bottom flask equipped with magnetic stirring bar and N2 inlet was charged with 3.0 g benzyl 3-(4-benzylpiperizin-1-ylsulfonyl)-2(R)-methylpropionate, 1.2 g LiOH (4 eq.) in 20 mL 50% aqueous methanol. After 2 hours HPLC analysis showed no starting material. The reaction was concentrated to half volume and partitioned between Et2O and H2O. The aqueous layer was acidified to pH 5 and extracted with 2×75 mL ethyl acetate. The combined organics were dried, and concentrated in vacuo to yield 550 mg (25%) white solid.

1. customA 100 mL round bottom flask equipped with magnetic stirring bar and N2 inlet
2. concentrationThe reaction was concentrated to half volume
3. custompartitioned between Et2O and H2O
4. extractionextracted with 2×75 mL ethyl acetate
5. customThe combined organics were dried
6. concentrationconcentrated in vacuo