HCID 67297923, compound → HCID 59253092, compound

HRID 884755Notes

Reaction equation

HRID 884755 reaction equation
C(OC(=O)[NH:7][N:8]1[C:17]([CH3:18])=[C:16]([C:19](=[O:29])[NH:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([I:28])[CH:23]=2)[C:15]2[C:10](=[C:11]([F:30])[CH:12]=[CH:13][CH:14]=2)[C:9]1=[O:31])(C)(C)C>C(#N)C>[I:28][C:24]1[CH:23]=[C:22]([CH:27]=[CH:26][CH:25]=1)[CH2:21][NH:20][C:19]([C:16]1[C:15]2[C:10](=[C:11]([F:30])[CH:12]=[CH:13][CH:14]=2)[C:9](=[O:31])[N:8]([NH2:7])[C:17]=1[CH3:18])=[O:29]

Participants

3

Reactant 1

HCID 67297923HCID 67297923, compound

Product 1

HCID 59253092HCID 59253092, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

[8-Fluoro-4-(3-iodo-benzylcarbamoyl)-3-methyl-1-oxo-1H-isoquinolin-2-yl]-carbamic acid tert-butyl ester in acetonitrile (prepared as described in example 8) was heated to remove the tert-butoxy carbonyl group as described in the synthesis of 2-amino-3-methyl-1-oxo-1,2-dihydro-isoquinoline-4-carboxylic acid ((S)-1-phenyl-propyl)-amide to give the title compound.

Workup

  1. customto remove the tert-butoxy carbonyl group
  2. customas described in the synthesis of 2-amino-3-methyl-1-oxo-1,2-dihydro-isoquinoline-4-carboxylic acid ((S)-1-phenyl-propyl)-amide

Sources & evidence

ORD record
ord-d06d0e6c4085422b9090321eb00719a0
Source dataset
uspto-grants-2012_08
Patent number
US08242134B2

Reaction notes

Loading…