HCID 67297923, compound → HCID 59253092, compound

Participants

Reaction Steps

[8-Fluoro-4-(3-iodo-benzylcarbamoyl)-3-methyl-1-oxo-1H-isoquinolin-2-yl]-carbamic acid tert-butyl ester in acetonitrile (prepared as described in example 8) was heated to remove the tert-butoxy carbonyl group as described in the synthesis of 2-amino-3-methyl-1-oxo-1,2-dihydro-isoquinoline-4-carboxylic acid ((S)-1-phenyl-propyl)-amide to give the title compound.

Provenance & Evidence