HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acumapimod → 3-(5-Amino-4-cyclopentanecarbonyl-pyrazol-1-yl)-N-cyclopropyl-4-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acumapimod | HCID 11338127 | — |
| Reactant | HCID 178419650 | HCID 178419650 | — |
| Product | 3-(5-Amino-4-cyclopentanecarbonyl-pyrazol-1-yl)-N-cyclopropyl-4-methylbenzamide | HCID 11772557 | — |
Reaction Steps
Similar procedure as in Example 17B except 3-[5-amino-4-(3-cyano-benzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methyl-benzamide was used in place of 3-(5-amino-4-cyano-imidazol-1-yl)-N-cyclopropyl-4-methyl-benzamide and cyclopentylmagnesium bromide was used in place of phenyl magnesium bromide. HPLC (4 minute 10-90 gradient) tR 2.54 min; MS m/z 353.19 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08242117B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-9733f5a9fc804dd689d3540460cdf581 |
| Source note | uspto-grants-2012_08 |