HCID 66880169, compound → HCID 136331269, compound

HRID 884915Notes

Reaction equation

HRID 884915 reaction equation
C([O:8][C:9]1[CH:10]=[N:11][CH:12]=[CH:13][C:14]=1[C:15]1[O:16][C:17]2[C:22]([N:23]=1)=[CH:21][C:20]([C:24]([F:27])([F:26])[F:25])=[CH:19][N:18]=2)C1C=CC=CC=1>[Pd].C(OCC)(=O)C>[F:26][C:24]([F:25])([F:27])[C:20]1[CH:21]=[C:22]2[N:23]=[C:15]([C:14]3[CH:13]=[CH:12][N:11]=[CH:10][C:9]=3[OH:8])[O:16][C:17]2=[N:18][CH:19]=1

Participants

4

Reactant 1

HCID 66880169HCID 66880169, compound

Product 1

HCID 136331269HCID 136331269, compoundYield 77.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 1.7 g of 2-[3-(benzyloxy)pyridin-4-yl]-6-trifluoromethyl-oxazolo[5,4-b]pyridine, 40 ml of ethyl acetate and 10% palladium on carbon was reacted under the conditions of 40 bar and 40° C. for two hours. The reaction solution was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to give 1.0 g of 4-(6-trifluoromethyl-oxazolo[5,4-b]pyridin-2-yl)pyridin-3-ol (hereinafter, referred to as “active compound 159”).

Workup

  1. customwas reacted under the conditions of 40 bar and 40° C. for two hours
  2. concentrationThe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-e45ae077b45b4064921307ba2f5bb3b2
Source dataset
uspto-grants-2012_08
Patent number
US08242133B2

Reaction notes

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