反应详情

温度

0 °C

To a mixture of 2.0 g of 3-chloroisonicotinonitrile and 8 ml of DMF, 1.02 g of sodium thiomethoxide was added while ice-cooling. The reaction mixture was stirred at 0° C. for one hour. The reaction mixture was concentrated under reduced pressure, to which ethyl acetate was added for filtering out insoluble matters. Filtrates were concentrated under reduced pressure, and the resultant residue was subjected to silica gel column chromatography to give 2.11 g of 3-methylthioisonicotinonitrile.

1. additionwas added while ice-
2. temperaturecooling
3. concentrationThe reaction mixture was concentrated under reduced pressure, to which ethyl acetate
4. additionwas added
5. filtrationfor filtering out insoluble matters
6. concentrationFiltrates were concentrated under reduced pressure