Lithium Hydroxide → {3-[2-(2-Oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid

HRID 885227Notes

Reaction equation

HRID 885227 reaction equation
C([O:3][C:4](=[O:26])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH2:19][N:20]2[CH2:24][CH2:23][O:22][C:21]2=[O:25])[CH:7]=1)C.[OH-].[Li+]>CO.O>[O:25]=[C:21]1[N:20]([CH2:19][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[O:12][C:8]2[CH:7]=[C:6]([CH2:5][C:4]([OH:26])=[O:3])[CH:11]=[CH:10][CH:9]=2)[CH2:24][CH2:23][O:22]1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 58237501{3-[2-(2-Oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid ethyl ester

Product 1

HCID 44187528{3-[2-(2-Oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

Hydrolysis of {3-[2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid ethyl ester with lithium hydroxide in MeOH and H2O provided the desired product.

Sources & evidence

ORD record
ord-81cec7c900294dcebfd78ead6652757a
Source dataset
uspto-grants-2012_08
Patent number
US08242145B2

Reaction notes

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