Sodium borohydride → HCID 58237585, compound

HRID 885229Notes

Reaction equation

HRID 885229 reaction equation
[CH2:1]([O:3][C:4](=[O:22])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=2[CH:20]=[O:21])[CH:7]=1)[CH3:2].[BH4-].[Na+]>CO>[CH2:1]([O:3][C:4](=[O:22])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=2[CH2:20][OH:21])[CH:7]=1)[CH3:2]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 58237566HCID 58237566, compound

Product 1

HCID 58237585HCID 58237585, compoundYield 104.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To [3-(4-fluoro-2-formyl-phenoxy)-phenyl]-acetic acid ethyl ester (0.35 g, 1.1 mmol) in MeOH (20 mL) was added sodium borohydride (0.052 g, 1.4 mmol), and the reaction was stirred for 10 minutes at room temperature. Once no starting material was seen by analytical tlc, the mixture was worked-up to give the desired product (0.35 g).

Sources & evidence

ORD record
ord-0ac423aeb82e4954b96e855fb4a67324
Source dataset
uspto-grants-2012_08
Patent number
US08242145B2

Reaction notes

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