Sodium hydride → {3-[4-Methyl-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid ethyl ester

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Reaction Steps

To 2-oxazolidone (0.06 g, 0.70 mmol) in 1,4-dioxane (10 mL) was added sodium hydride (60% in mineral oil; 0.03 g, 0.65 mmol), and the mixture was stirred for 10 minutes. [3-(2-Bromomethyl-4-methyl-phenoxy)-phenyl]-acetic acid ethyl ester (0.17 g, 0.43 mmol) was added in 1,4-dioxane, and the reaction was stirred for 1 hour at room temperature. After work-up, the crude material was purified by preparative HPLC to give the desired product (0.10 g).

Provenance & Evidence