関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Fluoro-5-(trifluoromethyl)benzaldehyde | HCID 2734904 | — |
| 反応物 | Methyl 3-hydroxy-4-methoxyphenylacetate | HCID 10465267 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | [3-(2-Formyl-4-trifluoromethyl-phenoxy)-4-methoxy-phenyl]-acetic acid methyl ester | HCID 58237485 | 23.5% |
反応手順
(3-Hydroxy-4-methoxy-phenyl)-acetic acid methyl ester (1 g, 5.2 mmol), 2-fluoro-5-(trifluoromethyl)benzaldehyde (1 g, 5.2 mmol), and potassium carbonate (1.3 g, 10.4 mmol) were combined in THF (10 mL) and heated to 65° C. for 8 hours. After working-up the mixture with H2O and EtOAc, the crude material was purified by silica gel chromatography to give the desired product as a white solid (0.45 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08242145B2 |
|---|
| 出典データセット | uspto-grants-2012_08 |
|---|
| ORD ID | ord-4ff72c026e594f03a09b736ee0fbf1b3 |
|---|
| 出典メモ | uspto-grants-2012_08 |
|---|
