反应详情

温度

85 °C

(2-Bromo-5-hydroxy-phenyl)-acetonitrile (1.4 g, 6.6 mmol) and potassium hydroxide (4.5 g, 78.9 mmol) were combined in tBuOH and stirred at 85° C. for 3 hours. Once no starting material was seen by analytical LCMS, the mixture was cooled to 0° C. and the pH was adjusted to pH 6 with 10% aqueous HCl. The solution was extracted with EtOAc to give the desired product as a colorless oil (1.5 g).

1. temperaturethe mixture was cooled to 0° C.
2. extractionThe solution was extracted with EtOAc