(5-Benzyloxy-2-chloro-phenyl)-acetic acid ethyl ester → (2-Chloro-5-hydroxy-phenyl)-acetic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4](=[O:21])[CH2:5][C:6]1[CH:11]=[C:10]([O:12]CC2C=CC=CC=2)[CH:9]=[CH:8][C:7]=1[Cl:20])[CH3:2]>CCO>[CH2:1]([O:3][C:4](=[O:21])[CH2:5][C:6]1[CH:11]=[C:10]([OH:12])[CH:9]=[CH:8][C:7]=1[Cl:20])[CH3:2]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 50 °C
Procedure
(5-Benzyloxy-2-chloro-phenyl)-acetic acid ethyl ester (1.7 g, 5.6 mmol) was dissolved in EtOH (30 mL) and degassed with N2. 5% Palladium on carbon (1 g) was added, and the reaction was purged with H2 and then stirred under an H2 balloon at 50° C. overnight. The mixture was filtered and concentrated to give the desired product (1 g).
Workup
- customdegassed with N2
- addition5% Palladium on carbon (1 g) was added
- customthe reaction was purged with H2
- filtrationThe mixture was filtered
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-4b6961fbbb7644289ea766ff558c8fa6
- Source dataset
- uspto-grants-2012_08
- Patent number
- US08242145B2
Reaction notes
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