HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Hydroxide → {5-[4-Bromo-2-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-ylmethyl)-phenoxy]-2-chloro-phenyl}-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | HCID 58237555 | HCID 58237555 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | {5-[4-Bromo-2-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-ylmethyl)-phenoxy]-2-chloro-phenyl}-acetic acid | HCID 44188253 | — |
Reaction Steps
Hydrolysis of {5-[4-bromo-2-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-ylmethyl)-phenoxy]-2-chloro-phenyl}-acetic acid ethyl ester (0.32 mmol) in 1,4-dioxane with aqueous lithium hydroxide, followed by purification by preparative HPLC, gave the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08242145B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-926481a6f65e46e5aeafcfd6b35f91f1 |
| Source note | uspto-grants-2012_08 |