Lithium Hydroxide → HCID 44188953, compound

HRID 885334Notes

Reaction equation

C[O:2][C:3](=[O:33])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][C:13]=2[CH2:19][N:20]2[C@@H:24]([CH2:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH2:23][O:22][C:21]2=[O:32])[CH:6]=1.[OH-].[Li+]>>[CH2:25]([C@H:24]1[CH2:23][O:22][C:21](=[O:32])[N:20]1[CH2:19][C:13]1[CH:14]=[C:15]([Br:18])[CH:16]=[CH:17][C:12]=1[O:11][C:7]1[CH:6]=[C:5]([CH2:4][C:3]([OH:33])=[O:2])[CH:10]=[CH:9][CH:8]=1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 58237459HCID 58237459, compound

Product 1

HCID 44188953HCID 44188953, compoundYield 47.3%

Procedure

Hydrolysis of {3-[2-((S)-4-benzyl-2-oxo-oxazolidin-3-ylmethyl)-4-bromo-phenoxy]-phenyl}-acetic acid methyl ester (0.49 mmol) with lithium hydroxide, followed by acidic work-up, yielded the desired product (0.115 g).

Sources & evidence

ORD record: ord-125e0585b83a40519b92481d1a225c7f
Source dataset: uspto-grants-2012_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08242145B2

Reaction notes

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