Potassium Carbonate → HCID 58237588, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole	HCID 2773987	—
Reactant	{3-[4-Bromo-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid ethyl ester	HCID 58237550	—
Catalyst	HCID 178418397	HCID 178418397	—
Solvent	1,2-Dimethoxyethane	HCID 8071	—
Product	HCID 58237588	HCID 58237588	—

Reaction Conditions

Temperature	80 °C

Reaction Steps

{3-[4-Bromo-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-phenyl}-acetic acid ethyl ester (0.1 g, 0.23 mmol), 1-methylpyrazole-4-boronic acid pinacol ester (0.06 g, 0.27 mmol), and potassium carbonate (0.1 g, 0.66 mmol) were combined in DME (3 mL) and H2O (1 mL) and degassed with N2 for 10 minutes. Tetrakis(triphenylphosphine)palladium(0) (0.025 g, 0.022 mmol) was added, and the reaction was stirred at 80° C. for 2 hours to give the title compound, which was directly as a crude solution in the hydrolysis step.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08242145B2
Source dataset	uspto-grants-2012_08
ORD ID	ord-634b9c59230b4fc697221375378ca1d7
Source note	uspto-grants-2012_08