HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → {3-[4-Chloro-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-4-methoxy-phenyl}-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | {3-[4-Chloro-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-4-methoxy-phenyl}-acetic acid ethyl ester | HCID 58237617 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | {3-[4-Chloro-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-4-methoxy-phenyl}-acetic acid | HCID 44187348 | — |
Reaction Steps
To {3-[4-chloro-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-4-methoxy-phenyl}-acetic acid ethyl ester (0.36 mmol) in 1,4-dioxane was added lithium hydroxide and H2O, and the reaction was stirred overnight at room temperature. The mixture was worked-up, and the residue was purified by preparative HPLC to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08242145B2 |
| Source dataset | uspto-grants-2012_08 |
| ORD ID | ord-f75deee3b011487fad3e45fef59eaecb |
| Source note | uspto-grants-2012_08 |