Lithium Hydroxide → {3-[4-Bromo-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-5-chloro-phenyl}-acetic acid

HRID 885376Notes

Reaction equation

HRID 885376 reaction equation
C([O:3][C:4](=[O:28])[CH2:5][C:6]1[CH:11]=[C:10]([Cl:12])[CH:9]=[C:8]([O:13][C:14]2[CH:19]=[CH:18][C:17]([Br:20])=[CH:16][C:15]=2[CH2:21][N:22]2[CH2:26][CH2:25][O:24][C:23]2=[O:27])[CH:7]=1)C.[OH-].[Li+]>CO.O>[Br:20][C:17]1[CH:18]=[CH:19][C:14]([O:13][C:8]2[CH:7]=[C:6]([CH2:5][C:4]([OH:28])=[O:3])[CH:11]=[C:10]([Cl:12])[CH:9]=2)=[C:15]([CH2:21][N:22]2[CH2:26][CH2:25][O:24][C:23]2=[O:27])[CH:16]=1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 58237451{3-[4-Bromo-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-5-chloro-phenyl}-acetic acid ethyl ester

Product 1

HCID 44187351{3-[4-Bromo-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-5-chloro-phenyl}-acetic acid

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

{3-[4-Bromo-2-(2-oxo-oxazolidin-3-ylmethyl)-phenoxy]-5-chloro-phenyl}-acetic acid ethyl ester (0.06 g, 0.13 mmol) in MeOH and H2O was treated with lithium hydroxide, and the reaction was stirred at 60° C. for 30 minutes to give the title compound.

Sources & evidence

ORD record
ord-109d67210c824d2197eab30e47144060
Source dataset
uspto-grants-2012_08
Patent number
US08242145B2

Reaction notes

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