(1R,2S)-(+)-cis-1-Amino-2-indanol → (3-{2-[((1R,2S)-2-Hydroxy-indan-1-ylamino)-methyl]-4-trifluoromethyl-phenoxy}-4-methoxy-phenyl)-acetic acid ethyl ester

HRID 885406Notes

Reaction equation

HRID 885406 reaction equation
[CH2:1]([O:3][C:4](=[O:27])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][C:16]=2[CH:25]=O)[CH:7]=1)[CH3:2].[CH2:28]1[C:36]2[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=2)[C@@H:30]([NH2:37])[C@H:29]1[OH:38]>>[CH2:1]([O:3][C:4](=[O:27])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([O:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:23])([F:22])[F:24])=[CH:17][C:16]=2[CH2:25][NH:37][C@@H:30]2[C:31]3[C:36](=[CH:35][CH:34]=[CH:33][CH:32]=3)[CH2:28][C@@H:29]2[OH:38])[CH:7]=1)[CH3:2]

Participants

3

Reactant 2

HCID 2725045(1R,2S)-(+)-cis-1-Amino-2-indanolHCID 58237587[3-(2-Formyl-4-trifluoromethyl-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester

Product 1

HCID 58237666(3-{2-[((1R,2S)-2-Hydroxy-indan-1-ylamino)-methyl]-4-trifluoromethyl-phenoxy}-4-methoxy-phenyl)-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 45, Step 3, using the following starting materials: [3-(2-Formyl-4-trifluoromethyl-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester and (1R,2S)-(+)-cis-1-amino-2-indanol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f54eb8ac2bad4a2fa62d741cf36f7c65
Source dataset
uspto-grants-2012_08
Patent number
US08242145B2

Reaction notes

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