Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | (1R,2R)-2-bromo-2,3-dihydro-1H-inden-1-ol | HCID 820607 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | (S)-2-Azido-indan-1-ol | HCID 58237515 | — |
Reaction Steps
trans-2-Bromo-1-indanol (2 g, 9.39 mmol) and sodium azide (0.915 g, 14.08 mmol) were combined in DMSO (20 mL) and stirred at 75° C. for 3 hours. The mixture was worked up with EtOAc and H2O, and the combined organic layers were dried and concentrated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08242145B2 |
|---|
| Source dataset | uspto-grants-2012_08 |
|---|
| ORD ID | ord-1c078deeb38d43a88c14b0c32864b8ed |
|---|
| Source note | uspto-grants-2012_08 |
|---|
