2,3-Diaminopyridine → HCID 178467385, compound

HRID 885422Notes

Reaction equation

HRID 885422 reaction equation
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:9]([O:11][C:12](OCC)(OCC)OCC)[CH3:10]>C(OCC)(=O)C>[CH2:9]([O:11][C:12]1[NH:1][C:2]2=[N:3][CH:4]=[CH:5][CH:6]=[C:7]2[N:8]=1)[CH3:10]

Participants

4

Reactant 2

HCID 99562,3-DiaminopyridineHCID 66213Tetraethyl orthocarbonate

Product 1

HCID 178467385HCID 178467385, compoundYield 36%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
130 °C

Procedure

2,3-Diaminopyridine (7.84 g, 71.9 mmol) and tetraethoxymethane (35 mL, 167 mmol) were mixed, and the mixture was stirred at 130° C. for 2 hr. The mixture was cooled to room temperature, ethyl acetate (100 mL) was added thereto and the precipitated solid was collected by filtration to give the title compound (4.17 g, 36%).

Workup

  1. temperatureThe mixture was cooled to room temperature
  2. filtrationthe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-7c78a923579f4027aa14b10f8b52cc96
Source dataset
uspto-grants-2012_08
Patent number
US08242151B2

Reaction notes

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