2-(2-Ethyl-5-methyl-7-trifluoromethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl-10,11-dihydro-5H-dibenzo[b,f]azepine → HCID 178437439, compound

HRID 885434Notes

Reaction equation

HRID 885434 reaction equation
[CH2:1]([C:3]1[N:16](CC2C=CC3NC4C=CC=CC=4CCC=3C=2)[C:6]2=[N:7][C:8]([CH3:15])=[CH:9][C:10]([C:11](F)(F)F)=[C:5]2[N:4]=1)[CH3:2].C(C1NC2=NC(C)=CC(C(F)(F)F)=C2N=1)C>>[CH2:1]([C:3]1[NH:16][C:6]2=[N:7][C:8]([CH3:15])=[CH:9][C:10]([CH3:11])=[C:5]2[N:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 690168742-(2-Ethyl-5-methyl-7-trifluoromethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl-10,11-dihydro-5H-dibenzo[b,f]azepineHCID 178437489HCID 178437489, compound

Product 1

HCID 178437439HCID 178437439, compound

Procedure

[step 1] 2-(2-Ethyl-5-methyl-7-trifluoromethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl-10,11-dihydro-5H-dibenzo[b,f]azepine (153 mg, 50%) was obtained in the same manner as in step 1 of Example 1, using 2-ethyl-5-methyl-7-trifluoromethyl-3H-imidazo[4,5-b]pyridine (160 mg, 0.700 mmol), obtained in Reference Example 3, instead of 2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine.

Sources & evidence

ORD record
ord-3cba9b9a3315475197280643827fa158
Source dataset
uspto-grants-2012_08
Patent number
US08242151B2

Reaction notes

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