(E)-2-[3-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl-6,11-dihydrodibenzo[b,e]oxepin-11-ylidene]propiononitrile → HCID 178437439, compound

HRID 885443Notes

Reaction equation

HRID 885443 reaction equation
[CH2:1]([C:3]1[N:13](CC2C=CC3=C(C=2)OCC2C=CC=CC=2/C/3=C(/C)\C#N)[C:6]2=[N:7][C:8]([CH3:12])=[CH:9][C:10]([CH3:11])=[C:5]2[N:4]=1)[CH3:2].OCC1C=CC2=C(C=1)OCC1C=CC=CC=1/C/2=C(/C)\C#N>>[CH2:1]([C:3]1[NH:13][C:6]2=[N:7][C:8]([CH3:12])=[CH:9][C:10]([CH3:11])=[C:5]2[N:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 69017955(E)-2-[3-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl-6,11-dihydrodibenzo[b,e]oxepin-11-ylidene]propiononitrileHCID 69018194(E)-2-(3-hydroxymethyl-6,11-dihydrodibenzo[b,e]oxepin-11-ylidene)propiononitrile

Product 1

HCID 178437439HCID 178437439, compoundYield 369.9%

Procedure

[step 1] (E)-2-[3-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl-6,11-dihydrodibenzo[b,e]oxepin-11-ylidene]propiononitrile (168 mg, 27%) was obtained in the same manner as in step 1 of Example 104, using (E)-2-(3-hydroxymethyl-6,11-dihydrodibenzo[b,e]oxepin-11-ylidene)propiononitrile (264 mg, 0.952 mmol) obtained in Reference Example 30 and 2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine (250 mg, 1.43 mmol).

Sources & evidence

ORD record
ord-e27b572bfb8c4620a16816ebbf03471d
Source dataset
uspto-grants-2012_08
Patent number
US08242151B2

Reaction notes

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