(Z)-2-(8-hydroxymethyl-6,11-dihydrodibenzo[b,e]oxepin-11-ylidene)propiononitrile → HCID 178437439, compound

HRID 885444Notes

Reaction equation

HRID 885444 reaction equation
[CH2:1]([C:3]1[N:13](CC2C=CC3/C(=C(\C)/C#N)/C4C=CC=CC=4OCC=3C=2)[C:6]2=[N:7][C:8]([CH3:12])=[CH:9][C:10]([CH3:11])=[C:5]2[N:4]=1)[CH3:2].OCC1C=CC2/C(=C(\C)/C#N)/C3C=CC=CC=3OCC=2C=1>>[CH2:1]([C:3]1[NH:13][C:6]2=[N:7][C:8]([CH3:12])=[CH:9][C:10]([CH3:11])=[C:5]2[N:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 67211541(Z)-2-(8-hydroxymethyl-6,11-dihydrodibenzo[b,e]oxepin-11-ylidene)propiononitrileHCID 69016353(Z)-2-[8-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl-6,11-dihydrodibenzo[b,e]oxepin-11-ylidene]propiononitrile

Product 1

HCID 178437439HCID 178437439, compoundYield 264%

Procedure

[step 1] (Z)-2-[8-(2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl-6,11-dihydrodibenzo[b,e]oxepin-11-ylidene]propiononitrile (158 mg, 57%) was obtained in the same manner as in step 1 of Example 104, using (Z)-2-(8-hydroxymethyl-6,11-dihydrodibenzo[b,e]oxepin-11-ylidene)propiononitrile (178 mg, 0.64 mmol) obtained in Reference Example 31 and 2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine (169 mg, 0.96 mmol).

Sources & evidence

ORD record
ord-cc0ba9c04864461b9e1593a593e08089
Source dataset
uspto-grants-2012_08
Patent number
US08242151B2

Reaction notes

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