反应详情

[step 1] (Z)-2-[8-(2-Cyclopropyl-4-methylbenzimidazol-1-yl)methyl-6,11-dihydrodibenzo[b,e]oxepin-11-ylidene]propiononitrile (764 mg, 89%) was obtained in the same manner as in step 1 of Example 140, using 2-cyclopropyl-4-methylbenzimidazole (342 mg, 1.98 mmol), obtained in Reference Example 28, instead of 2-ethyl-4,6-dimethylbenzimidazole.