(Z)-2-[8-(2-Cyclopropyl-4-methylbenzimidazol-1-yl)methyl-6,11-dihydrodibenzo[b,e]oxepin-11-ylidene]propiononitrile → HCID 178437417, compound

HRID 885446Notes

Reaction equation

HRID 885446 reaction equation
[CH:1]1([C:4]2[N:8](CC3C=CC4/C(=C(\C)/C#N)/C5C=CC=CC=5OCC=4C=3)[C:7]3[CH:29]=[CH:30][CH:31]=[C:32]([CH3:33])[C:6]=3[N:5]=2)[CH2:3]C1.[CH:34]1(C2NC3C(C)=CC=CC=3N=2)CC1>>[CH2:1]([C:4]1[NH:5][C:6]2[C:32]([CH3:33])=[CH:31][C:30]([CH3:34])=[CH:29][C:7]=2[N:8]=1)[CH3:3]

Participants

3

Reactant 2

HCID 69016635(Z)-2-[8-(2-Cyclopropyl-4-methylbenzimidazol-1-yl)methyl-6,11-dihydrodibenzo[b,e]oxepin-11-ylidene]propiononitrileHCID 178423935HCID 178423935, compound

Product 1

HCID 178437417HCID 178437417, compound

Procedure

[step 1] (Z)-2-[8-(2-Cyclopropyl-4-methylbenzimidazol-1-yl)methyl-6,11-dihydrodibenzo[b,e]oxepin-11-ylidene]propiononitrile (764 mg, 89%) was obtained in the same manner as in step 1 of Example 140, using 2-cyclopropyl-4-methylbenzimidazole (342 mg, 1.98 mmol), obtained in Reference Example 28, instead of 2-ethyl-4,6-dimethylbenzimidazole.

Sources & evidence

ORD record
ord-abf893799efc4db9a95d190ecfb16761
Source dataset
uspto-grants-2012_08
Patent number
US08242151B2

Reaction notes

Loading…