反应详情

温度

-78 °C

20.0 g (125.6 mmol) of 5-cyanophthalimide was dissolved in 200 ml of anhydrous dichloromethane. The solution was cooled to −78° C., and 188 ml of 4-methoxyphenylmagnesium bromide (1 M in THF, 188 mmol) was added dropwise. The mixture was raised to room temperature and stirred for 16 hrs, followed by addition of a saturated ammonium chloride solution. An organic layer was dried over anhydrous magnesium sulfate, and filtered. The solvent was evaporated under reduced pressure, thereby yielding a yellow compound, represented by Formula 3. The compound thus obtained was used in the next reaction without further purification.

1. temperatureThe mixture was raised to room temperature
2. dry with materialAn organic layer was dried over anhydrous magnesium sulfate
3. filtrationfiltered
4. customThe solvent was evaporated under reduced pressure
5. customyielding a yellow compound
6. customThe compound thus obtained
7. customwas used in the next reaction without further purification