Ammonium Chloride → HCID 67545412, compound

Participants

Reaction Conditions

Reaction Steps

20.0 g (125.6 mmol) of 5-cyanophthalimide was dissolved in 200 ml of anhydrous dichloromethane. The solution was cooled to −78° C., and 188 ml of 4-methoxyphenylmagnesium bromide (1 M in THF, 188 mmol) was added dropwise. The mixture was raised to room temperature and stirred for 16 hrs, followed by addition of a saturated ammonium chloride solution. An organic layer was dried over anhydrous magnesium sulfate, and filtered. The solvent was evaporated under reduced pressure, thereby yielding a yellow compound, represented by Formula 3. The compound thus obtained was used in the next reaction without further purification.

Provenance & Evidence