Hydrochloric Acid → HCID 42606392, compound

Participants

Reaction Steps

8.3 g (24.7 mmol) of the 1-{3-(dimethylamino)propyl}-1-(4-methoxyphenyl)-1,3-dihydro-5-isobenzofurancarbonitrile prepared in Example 1 was dissolved in 50 ml of dichloromethane, and 24.7 ml (494 mmol) of 2 M hydrochloric acid in diethyl ether was added dropwise at room temperature. The mixture was then stirred for 0.5 hr. After the solution was discarded, the precipitate was washed with diethylether and dried to afford 8.7 g of the pale yellow target compound (yield: 95%).

Provenance & Evidence